Impact of human coronavirus infections in otherwise healthy children who attended an emergency department
Identifieur interne : 004255 ( Main/Exploration ); précédent : 004254; suivant : 004256Impact of human coronavirus infections in otherwise healthy children who attended an emergency department
Auteurs : Susanna Esposito [Italie] ; Samantha Bosis [Italie] ; Hubert G. M. Niesters [Pays-Bas] ; Elena Tremolati [Italie] ; Enrica Begliatti [Italie] ; Alessandro Rognoni [Italie] ; Claudia Tagliabue [Italie] ; Nicola Principi [Italie] ; Albert D. M. E. Osterhaus [Pays-Bas]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2006-12.
English descriptors
- Teeft :
- Acute disease, Acute diseases, Adenovirus, Antibiotic prescriptions, Antipyretic prescriptions, Bastien, Chiu, Clin, Clin virol, Clinical impact, Clinical importance, Clinical outcomes, Clinical presentation, Coronavirus, Coronaviruses, Diagnostic methods, Emergency department, Esposito, Fondazione irccs, Genotype, Hcov, Hcov infection, Hcov strain, Hcov strains, Hcovs, Healthy children, Healthy infants, Hku1 genotype, Hmpv, Hoek, Hospital admission, Household contacts, Human coronavirus, Human coronavirus hku1, Human coronavirus infections, Human coronaviruses, Human metapneumovirus, Infection, Limited number, Limited pathogenicity, Limited role, Mcintosh, Medical history, Medical visits, Milan institute, Nasopharyngeal aspirates, Novel coronavirus, Nucleoprotein gene, Ospedale maggiore policlinico, Other differences, Other members, Polymerase chain reaction, Principi, Prospective study, Qualitative role, Regina elena, Respiratory syncytial virus, Respiratory syndrome, Respiratory tract disease, Respiratory tract infections, Respiratory virus, Respiratory viruses, Rhinovirus, School days, Sibling, Single hcov infection, Single hcov infections, Socioeconomic impact, Study children, Study population, Therapeutic approaches, Tract infection, Tract infections, Virol, Virological study, Winter season, Young children.
Abstract
This prospective clinical and virological study of 2,060 otherwise healthy children aged <15 years of age (1,112 males; mean age ± SD, 3.46 ± 3.30 years) who attended the Emergency Department of Milan University's Institute of Pediatrics because of an acute disease excluding trauma during the winter season 2003–2004 was designed to compare the prevalence and clinical importance of human coronaviruses (HCoVs) in children. Real‐time polymerase chain reaction (PCR) in nasopharyngeal aspirates revealed HCoV infection in 79 cases (3.8%): 33 HCoV‐229E (1.6%), 13 HCoV‐NL63 (0.6%), 11 HCoV‐OC43 (0.5%), none HCoV‐HKU1 genotype A, and 22 (1.1%) co‐detections of a HCoV and another respiratory virus. The HCoVs were identified mainly in children with upper respiratory tract infection; there was no significant difference in clinical presentation between single HCoV infections and HCoV co‐infections. Diagnostic methods were used in a limited number of patients, and the therapy prescribed and clinical outcomes were similar regardless of the viral strain. There were a few cases of other members of the households of HCoV‐positive children falling ill during the 5–7 days following enrollment. These findings suggest that HCoV‐229E and HCoV‐OC43 have a limited clinical and socioeconomic impact on otherwise healthy children and their household contacts, and the HCoV‐NL63 identified recently does not seem to be any different. The quantitative and qualitative role of HCoV‐HKU1 genotype A is apparently very marginal. J. Med. Virol. 78:1609–1615, 2006. © 2006 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.20745
Affiliations:
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Real‐time polymerase chain reaction (PCR) in nasopharyngeal aspirates revealed HCoV infection in 79 cases (3.8%): 33 HCoV‐229E (1.6%), 13 HCoV‐NL63 (0.6%), 11 HCoV‐OC43 (0.5%), none HCoV‐HKU1 genotype A, and 22 (1.1%) co‐detections of a HCoV and another respiratory virus. The HCoVs were identified mainly in children with upper respiratory tract infection; there was no significant difference in clinical presentation between single HCoV infections and HCoV co‐infections. Diagnostic methods were used in a limited number of patients, and the therapy prescribed and clinical outcomes were similar regardless of the viral strain. There were a few cases of other members of the households of HCoV‐positive children falling ill during the 5–7 days following enrollment. These findings suggest that HCoV‐229E and HCoV‐OC43 have a limited clinical and socioeconomic impact on otherwise healthy children and their household contacts, and the HCoV‐NL63 identified recently does not seem to be any different. The quantitative and qualitative role of HCoV‐HKU1 genotype A is apparently very marginal. J. Med. Virol. 78:1609–1615, 2006. © 2006 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li><li>Lombardie</li></region><settlement><li>Milan</li><li>Rotterdam</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Esposito, Susanna" sort="Esposito, Susanna" uniqKey="Esposito S" first="Susanna" last="Esposito">Susanna Esposito</name></region><name sortKey="Begliatti, Enrica" sort="Begliatti, Enrica" uniqKey="Begliatti E" first="Enrica" last="Begliatti">Enrica Begliatti</name><name sortKey="Bosis, Samantha" sort="Bosis, Samantha" uniqKey="Bosis S" first="Samantha" last="Bosis">Samantha Bosis</name><name sortKey="Principi, Nicola" sort="Principi, Nicola" uniqKey="Principi N" first="Nicola" last="Principi">Nicola Principi</name><name sortKey="Principi, Nicola" sort="Principi, Nicola" uniqKey="Principi N" first="Nicola" last="Principi">Nicola Principi</name><name sortKey="Principi, Nicola" sort="Principi, Nicola" uniqKey="Principi N" first="Nicola" last="Principi">Nicola Principi</name><name sortKey="Rognoni, Alessandro" sort="Rognoni, Alessandro" uniqKey="Rognoni A" first="Alessandro" last="Rognoni">Alessandro Rognoni</name><name sortKey="Tagliabue, Claudia" sort="Tagliabue, Claudia" uniqKey="Tagliabue C" first="Claudia" last="Tagliabue">Claudia Tagliabue</name><name sortKey="Tremolati, Elena" sort="Tremolati, Elena" uniqKey="Tremolati E" first="Elena" last="Tremolati">Elena Tremolati</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Niesters, Hubert G M" sort="Niesters, Hubert G M" uniqKey="Niesters H" first="Hubert G. M." last="Niesters">Hubert G. M. Niesters</name></region><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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